I recently implemented a new CX4 with the latest version of Navisphere, FLARE 29. There's been a lot of hype around this release because 29 now gives storage admins the ability to peer into VMware environments and even see which guest VMs exist on which LUNs. ESX hosts icons appear differently and are easy to decipher form other hosts. I really like the integration and setup was straight forward. Just a quick wizard to run through that requires authentication to your virtual center server and your good to go. I've only tested the new FLARE in with vsphere so I'm not sure if the interface would give similar results and visibility into a VI3.5 environment.
Another change in FLARE 29 that appears simple at first but, in my opinion, is quite a great enhancement is an upgrade to the "connectivity status" section of Navisphere. Host wwn's and iqn's are now grouped together in a tree structure under the hostname. No more sorting and trying to figure out if all your initiators registered successfully or not! What a time save if you're implementing several new hosts in an environment.
CAUTION: It does appear that there is a bug with FLARE 29 and Site Recovery Manager. If using SRM with MirrorView, hold off until the next version of SRM is released and do the SRM upgrade first. Hopefully, this will also be the time a vSphere compatible version of SRM is released as well. For more information about this issue, check out the end of this fine article from Chad Sakac.
http://virtualgeek.typepad.com/virtual_geek/2009/09/a-couple-important-alua-and-srm-notes.html